FACULTY'S RESEARCH INTERESTS

James Donadio, MD: Glomerulonephrotis.
Teh-Li Huo, MD, PhD: Calcium channel, Dopamine receptor, Signal transduction.
Sam James, MD: Cardiovascular complications in renal patients, Hypertension.
Murray Katz, MD: Microcirculation, Diabetic nephropathy.
Y. Howard Lien, MD, PhD: Gene therapy, Osmoregulation, Acidosis, Acute renal failure.
Joy Logan, MD: Chronic renal failure, Renal aging.
Ulrich Michael, MD: Renal physiology, Renal failure, Compensatory renal growth
Eric Prosnitz, MD: Clinical nephrology
David Van Wyck, MD: Anemia, Iron metabolism, Erythropoitin

Publications (1993-present)

(* fellow, underline: faculty)

*Ruffenach, S.J., Siskind, M.S., and Lien, Y.H. (1993) Acute interstitial nephritis due to omeprazole. Am. J. Med. 93:472-473.

Lien, Y.H., Pacelli, M.M., and Braun, E.J. Braun. (1993) Characterization of organic osmolytes in the avian renal medulla: a non-urea osmotic gradient system. Am. J. Physiol. 264:R1045-1049.

Gillies, R.J., Galons, J-P, McGovern, K.A., Scherer, P.G., Lien, Y.H., Job, C., Ratcliff, R., Chapa, F., Cerdan, S., and Dale. B.E. (1993) Design and application of NMR-compatible bioreactor circuits. NMR Biomed 6:95-104.

Barry J.A., McGovern K.A., Lien, Y.H., Ashmore B., Gillies, R.J. (1993) Dimethylmethylphosphonate as a volume marker in the in vivo ³¹P NMR of mammalian cell cultures. Biochemistry 32:4665-4670.

Diaz RJ, Washburn S. Cauble L. Siskind MS, Van Wyck D. (1993) The effect of dialyzer reprocessing on performance and Beta-2 microglobulin removal using polysulfone membranes. Am J Kidney Dis. 21:405-410.

Lien, Y.H., Hunt, K.R., Siskind, M., Zukoski, C. (1993) Cyclosporine A is associated with acquired cystic kidney disease in renal transplant recipients. Kidney Int. 44: 613-616.

Lien, Y.H., Hansen R., Kern, W.F., Bangert, J., Nagle, R.B., Ko M., and Siskind, M.S. (1993). Ciprofloxacin-induced granulomatous interstitial nephritis and elastolysis. Am. J. Kidney Dis. 22:598-602.

Moats, RA., Lien, Y.H., Fillips D., Ross B.D. (1993). Depletion of cerebral inositols in rats and humans. Biochem J. 295:15-18.

Siskind M.S., Lien Y.H. (1993). Effect of intradialytic parental nutrition (IDPN) on quality of life in hemodialysis patients. Int J Artif Organ 16:353-357.

Lien, Y.H. Moats R., Michaelis T., Ross B.D. (1994). Scyllo-inositol in autopsied brain tissue from patients with hepatic encephalopathy. Life Sci. 54:1507-1512.

Moeckel G.W. and Lien Y.H. (1994) Bicarbonate dependency of betaine synthesis in cultured LLC-pK1 cells. Am J Physiol. 266:F512-515.

Lien, Y.H., Pacelli, M.M., and Braun, E.J. Braun. (1994) Serine ethanolamine phosphodiester as a major chicken kidney metabolite. (letter) Am. J. Physiol. R1720-1721.

Katz MA, LaMarche, M (1994) Fibermatrix descriptors from permeability data without requiring membrane thickness: Theory, results and optimization. Microcirculation 1:111-119.

Sanderson N., Katz MA. (1994) The fate of hypertonic saline administered during hemodialysis. Am. Nephrol. Nurses Assoc. J. 21:162-170.

Logan JL, Michael UF. (1994) Atrial natriuretic peptide retards compensatory renal growth in uninephrectomized rats. J Am Soc Nephrol 4:2016-2022.

Logan JL. (1995) Studies on renal growth regulation by urea and ammonium in NRK-52 E cells. Nephron 71:433-441.

Lien, Y.H. (1995). Role of organic osmolytes in myelinolysis: a topographic study in rats after rapid correction of hyponatremia. J. Clin. Invest. 95:1579-1586.

Lien, Y.H, Wang X., Gillies R.J., and Martinez-Zaguilan R (1995). Modulation of intracellular calcium by glucose in MDCK cells: role of endoplasmic reticulum Ca²⁺ -ATPase. Am J. Physiol. 268:F671-679.

*James, S.H., Lien, Y.H., Ruffenach, SJ., Wilcox, G.E. (1995) Acute renal failure in membranous glomerulopathy: a result of superimposed crescentic glomerulonephritis. J. Am. Soc. Nephrol. 6:1541-1546.

Wang X., Lien, Y.H, Gillies R.J., and Martinez-Zaguilan R (1995). Glucose reduces intracellular calcium and pH cultured rat vascular smooth muscle cells: role of Ca²⁺ -ATPase. Cell. Physiol. Biochem. 5:299-312.

Lien, Y.H., Wang X, and Martinez-Zaguilan R. (1995) Differential Effects of Endoplasmic Reticulum Ca²⁺-ATPase Inhibitors on Madin Darby Canine Kidney (MDCK) Cells. Cell. Physiol. Biochem. 5:371-379

Katz MA, LaMarche M. (1995) Albumin reduces basement membrane hydraulic conductance in part due to arginyl side groups. Am J. Physiol. 269: H1514-H1521.

James SH. Meyers AM. Milne FJ. Reinach SG. (1995) Partial recovery of renal function in black patients with apparent end-stage renal failure due to primary malignant hypertension. Nephron. 71(1):29-34

Katz MA, LaMarche M. (1996) Basement membrane (Matrigel 1) compresses greatly even at low pressures. Microvasc. Res. 51:121-125.

Roe DJ. Harford AM. Zager PG. Wiltbank TB. Kirlin L. Della Valle AM. Van Wyck DB. (1996) Iron utilization after iron dextran administration for iron deficiency in patients with dialysis-associated anemia: a prospective analysis and comparison of two agents. Am. J. Kidney Dis. 28(6):855-60.

Galons J.P., Trouard T., Gmitro A., Lien YH. (1996). Hemodialysis increases apparent diffusion coefficient of brain water in nephrectomized rats measured by isotropic diffusion-weighted magnetic resonance imaging. J. Clin. Invest. 98:750-755.

Lien Y.H., Ruffenach SJ. (1996). Low dose megestrol increases serum albumin in malnourished dialysis patients. Int. J. Artif. Organ. 19:147-150.

*Lu C.C., James S.H., and Lien Y.H. (1996). Acute massive gentamicin intoxication in a patient with end stage renal disease. Am. J. Kidney Dis. 28:767-771.

Fernandez MC, Walter FG, Kloster JC, *O'Brien SM, Brady LA, Villarin A, Ruffenach SJ, Prosnitz EH, Salmon JV. (1996) Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning. Vet. Human Toxicol. 38(6):438-43.

Lien Y.H., Lai L. (1997). Liposome-mediated gene transfer into the tubules. Exp. Nephrol. 5:132-136.

Moeckel G.W., Lien Y.H. (1997). Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on betaine accumulation in the medulla. Am J Physiol. 272:F94-F99.

Moeckel G.W., Lai, L., Guder W.G., Kwon H.M., Lien Y.H. (1997). Kinetics and osmoregulation of Na+, Cl--dependent betaine transporter in rat renal medulla. Am. J. Physiol. 272:F100-F106.

Lai L., Moeckel G.W., Lien Y.H. (1997) Kidney-targeted liposome-mediated gene transfer in mice. Gene Ther. 4:426-431.

Lien Y.H., Lai L. (1997) Gene therapy for renal diseases. Kidney Int. (in press)

*O'Brien S, Bernert R.A., Logan L.L., Lien Y.H. (1997). Remission of post-transplant lymphoproliferative disorder after interferon alfa therapy. J. Am. Soc. Nephrol. (in press)