Y. Howard Lien, MD, PhD
Professor of Medicine
Chief, Section of Nephrology
 

MD	National Taiwan University  College of Medicine
PhD	University of California  San Francisco
Residency	University of Texas Southwestern Medical School  At Dallas
Fellowship	University of Colorado
Email	Lien@u.arizona.edu

 
Research Interests:
Gene therapy, Osmoregulation, Fabry disease, Anemia, Acidosis, Acute renal failure.

Publications:
Lien, Y.H. (1995). Role of organic osmolytes in myelinolysis: a topographic study in rats after rapid correction of hyponatremia. J. Clin. Invest. 95:1579-1586.

Galons J.P., Trouard T., Gmitro A., Lien YH. (1996). Hemodialysis increases apparent diffusion coefficient of brain water in nephrectomized rats measured by isotropic diffusion-weighted magnetic resonance imaging. J. Clin. Invest. 98:750-755.

Lien Y.H., Lai L. (1997). Liposome-mediated gene transfer into the tubules. Exp. Nephrol. 5:132-136.

Moeckel G.W., Lien Y.H. (1997). Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on betaine accumulation in the medulla. Am J Physiol. 272:F94-F99.

Moeckel G.W., Lai, L., Guder W.G., Kwon H.M., Lien Y.H. (1997). Kinetics and osmoregulation of Na+, Cl--dependent betaine transporter in rat renal medulla. Am. J. Physiol. 272:F100-F106.

Lai L., Moeckel G.W., Lien Y.H. (1997) Kidney-targeted liposome-mediated gene transfer in mice. Gene Ther. 4:426-431.

Lai L., Chan D., Erickson R.P., Hsu S.J., Lien Y.H. (1998) Correction of renal tubular acidosis in carbonic anhydrase II deficient mice with gene therapy. J. Clin Invest. 101:1320-1325.

Lai L, Lien YH. (1999) Homologous recombination-based gene therapy. Mini-review. Exp. Nephrol. 7:11-14.

Lai L, Lien YH. (2001) Therapeutic application of chimeric RNA/DNA oligonucleotide based gene therapy. Exp Opin Biol Ther 1:41-47.

Wu M, Lai L, Lien YH (2002) Cytoprotective effects of calbindin-D_28k against antimycin-A induced hypoxic injury in proximal tubular cells. Life Sci. 71:559-569.

Lai L, Lien YH. (2002) Chimeric RNA/DNA oligonucleotide based gene therapy. Kidney Int. 61 Suppl 1:47-51.

Pastores GM, Lien YH (2002) Biochemical and Molecular Genetic Basis of Fabry Disease: Diagnostic and Counseling Issues. J Am Soc Nephrol. 13 Suppl 2:S130-133.

Lee CT, Huynh VM, Lai L, Lien YH (2002) Cyclosporine A-induced hypercalciuria in calbindin-D28k knockout and wild type mice. Kidney Int 62:2055-2061.